User can remove the limitations/weaknesses of anyone/anything, allowing them to bestow powers such as immortality, invulnerability, perfection and possibly more. Depending on the weaknesses removed, the effect may be either permanent or temporary.
Ajimu Najimi (Medaka Box); via Weak Pointless skill
Evangeline A.K. McDowell (Mahou Sensei Negima)
HIM (The Powerpuff Girls)
Alex Mercer (Prototype)
Katherine Pierce (The Vampire Diaries)
Gem of Amara (Buffy the Vampire Slayer)
Sephiroth Graal (Highschool DxD)
Red Stone of Aja (Jojo's Bizarre Adventure)
Varia Suit (Metroid Fusion)
When worn, the Gem of Amara (Buffy the Vampire Slayer) removes all of a vampire's weaknesses, such as sunlight and wooden stakes.
Through mass absorption of solar energy, the Superman of the Kingdom Come universe (DC Comics) was able to remove his weakness to Kryptonite.
Through extensive training, Saiyans (Dragon Ball series) like Son Goku are able to remove their longtime weakness of having their tails squeezed.
The Bat Gremlin (Gremlins 2: The New Batch) removed itself of its vulnerability to sunlight after being modified with genetic sunblock.
By consuming the soul of his brother Rahab, Raziel (Legacy of Kain) was able to remove his vulnerability to water, enabling him to survive immersion in water and thus swim.
Evangeline A.K. McDowell (Mahou Sensei Negima) was once vulnerable to sunlight, but was able to remove said vulnerability as she became more powerful.
While Samus Aran (Metroid) was initially vulnerable to cold due to being treated with the Metroid vaccine, she was able to rid herself of that weakness upon acquiring the Varia Suit.
When HIM (The Powerpuff Girls) revived the Rowdyruff Boys, he added a cootie vaccination, not only removing their weakness to the kisses that killed them before, but causing them to grow bigger with each one.
Through repeated exposure to the Anti-Blacklight Toxin Bloodtox, Alex Mercer (Prototype) was able to remove his vulnerability to it.
After drinking the blood of Alexander Corvinus, Selene (Underworld) was able to remove her vulnerability to sunlight.
By repeatedly ingesting vervain-laced liquids, Katherine Pierce (The Vampire Diaries) was able to remove her vulnerability to it.
After acquiring the Red Stone of Aja, Kars (Jojo's Bizarre Adventure) rid himself of his vulnerability to sunlight.
Using the magic of the Darkhold, Carnage (Marvel Comics) was able to remove his weakness to sonic vibrations.