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- Depression Affinity/Depression
- Humiliation Affinity/Empowerment
- Melancholy Affinity/Empowerment
- Sadness Affinity
- Misery Empowerment/Affinity
- Sorrow Affinity/Empowerment
Users become stronger, faster, more durable, etc. by sadness of oneself and others, possibly unlocking abilities related to the affinity and enhancing the existing powers. Some users may be able draw sustenance from the sadness or even slow or stop aging.
- Decelerated Aging/Semi-Immortality
- Enhanced Condition or Supernatural Condition
- Self-Power Augmentation
- Penelope Spectra (Danny Phantom)
- Kenshiro (Hokuto No Ken); via Musou Tensei
- HIM (Powerpuff Girls)
- Lankin (Class)
- Nighlok (Power Rangers)
- Ryoga Hibiki (Ranma 1/2)
- Shiego Kageyama (Mob Psycho 100); via 100% Sadness Mode
- Freeze (Kamen Rider Drive); Humiliation