Some immensely strong and powerful Objects in fictional universes (such as the DC, Marvel, W.I.T.C.H) can grant numerous superpowers to the wielder. Some of these objects are sentient and have a mind and will of their own and can even take full possession of their host's mind and body if the host is in grave danger, or when the host is angered or enraged. These sentient artifacts/objects can even speak through their host when it takes full control over the host's body and mind. Most items are accompanied by Powers Via Object.
Tessaiga (Inuyasha), Inuyasha's traditional weapon.
Devil Fruits (One Piece) grant the eater special powers, at the cost of the user being rendered permanently unable to swim.
The Death Note (Death Note)
The Dragon Balls (Dragon Ball series).
The Power Pole (Dragon Ball)
The Cyber Planet Keys (Transformers: Cybertron)
The Skyboom Shield (Transformers: Armada). Strongest defensive force in the universe. Capable of withstanding the Star saber and the Requiem Blaster
The Star Saber (Transformers Armada) is one of the three most powerful weapons in the known galaxy. Not only does it posses incredible cutting power, but its Mini-Con power enhancing technology allows it to increase the strength and combat prowess of any Cybertronian who wields it, allowing them to battle on par with better skilled soldiers.
The Requiem Blaster (Transformer: Amarda) is the most powerful energy weapon in the galaxy. Being able to draw power from celestials bodies, the weapon can harness the power of a supernova and unleash it with the intense gravity of blackhole.
The 12 Talismans of Shendu (Jackie Chan Adventures)
The 12 Powerbands (Legend of the Dragon)
Ascalon (Ben 10)
Omega-1 Nanite (Generator Rex)
The Meta-Nanites (Generator Rex) are extremely powerful nanites that allow the user control over the fabric of the universe: gravity, matter and energy, time and space, elemental forces, mechanics, etc.
The Mask of Loki brings the wearer's innermost desires to the surface. (The Mask)
Elements of Harmony (My Little Pony: Friendship is Magic)
Alicorn Amulet (My Little Pony: Friendship is Magic)
The Gem of Amara (Buffy the Vampire Slayer/Angel) renders any vampire who wears it immune to his/her conventional weaknesses.
The Scythe (Buffy the Vampire Slayer)
Several examples of the Shen Gong Wu (Xiaolin Showdown)
The Reality Gauntlet (Danny Phantom)
The Book of Shadows (Charmed)
The First Blade (Supernatural) can kill anything, and is the only known weapon able to kill the Knights of Hell, but is completely useless unless the wielder also possesses the Mark of Cain.
The Colt (Supernatural) can kill any supernatural creature with one shot with the exception of five.
Death's Scythe (Supernatural) is capable of reaping anyone & anything. Angels, demons, reapers,deities, and even Death himself.
The Elder Wand (Harry Potter)
The Gauntlet of Billy. (Adventure Time)
The Heart of Kandrakar. (W.I.T.C.H.)
The Charms of Bezel. (Ben 10)
Jack's sword (Samurai Jack), the only weapon that can truly harm the demon Aku.
The Good Samaritan (Hellboy)
The Eleventh Doctor holding the Sonic Screwdriver (Doctor Who)
The Four Power Stones (Thundercats 2011)
There are a number of stones, crystals, and minerals that used in the construction of light-sabers that yield a variety of results. (Star Wars)
The Phoenix Gate (Gargoyles)
The Eye of Odin (Gargoyles)
The proton packs (Ghostbusters) are the signature weapons of the Ghostbusters.
Hard Drive's Surge Coat (S.W.A.T. Kats: The Radical Squadron)
The Devo Chamber (Super Mario Bros. film) forces Devolution.
President Koopa later adapted the technology into the portable Devolution Gun.
The Power Sneakers (Sonic the Hedgehog), Sonic's iconic footwear, help reduce friction on Sonic's feet to allow him to run at his full potential.
Chaos Crystals (Sonic Boom)
The Master Sword (Legend of Zelda)
Mysterio standing before the Tablet of Order and Chaos (Spider-Man: Shattered Dimensions)
Super Mushroom (Mario)
1-UP Mushroom (Mario)
Mega Mushroom (Mario)
The Blades of Chaos (God of War)
The Blades of Exile (God of War)
Heart Container (Legend of Zelda)
The Star Rod (Mario/Kirby)
The Keyblade] (Kingdom Hearts)
Ezio holding one of the Apples of Eden (Assassins Creed)
The Swords of Sparda (Devil May Cry)
The Magic Armor (The Legend of Zelda: The Wind Waker) grants an invincible defense.
The Magic Armor (The Legend of Zelda: Twilight Princess) makes the wearer invincible.
The Phantom Sword (Legend of Zelda: Phantom Hourglass) was forged by protectors of the Ocean King with the power to destroy phantoms as well as slow down time.
The Lokomo Sword (Legend of Zelda: Spirit Tracks' is infused with sacred energy that is capable of stunning phantoms.
Samus Aran's Power Suit (Metroid)
The Soul Edge (Soul Calibur)
The Soul Calibur (Soul Calibur)
The Soul Reaver (Legacy of Kain)
The sacred golden power of the gods, The Triforce. (Legend of Zelda series)
The Vampire Killer (Castlevania), the Belmont clan's legendary whip, is able to harm any vampiric or demonic entity, even divine beings such as Death himself.
The Precursor Stone (Jak and Daxter)
The Mantra Reactor (Asura's Wrath)
The Wailing Dark (Asura's Wrath) is Augus' favored weapon. It is capable of deliver energy slashes, slicing part of the moon, and even extending to miles that seem endless.
The Dragon Sword] (Ninja Gaiden) is Ryu Hayabusa's signature weapon.
The Dragon Blade (Naruto Shippūden: Dragon Blade Chronicles).
Mega Stone and Key Stone (Pokemon)
Z-Ring and Z-Crystal (Pokemon)
Clank holding the Chronoscepter (Ratchet & Clank)
The Paintbrush. (Epic Mickey)
Ocarina of Time (Legend of Zelda: Ocarina of Time)
The Power Stones (Power Stone series) are legendary stones of mysterious power that are said to make dreams come true. When three are collected, the collector is able to access a Power Change to become a more powerful version of himself/herself
In the Power Stone anime, there are seven Power Stones, each able to grant its bearer incredible power. When the seven stones are united, they are able to create the Light Stone and bring about an age of mircales and wonder.
Lucille (Channel Awesome), also known as the "Hammer of Power", is an ancient artifact disguised as a regular claw-hammer that grants those who are worthy the powers and title of the Blockbuster Buster.
Linkara's Magic Gun (Channel Awesome) is a toy gun that is imbued with powerful magics. Such power comes from the soul of a tortured girl grafted into it by a cult from Silent Hill.
Malachite's Hand (Channel Awesome) was a powerful artifact that grants the user limitless magical power. Because the original gauntlet was old and unfashionable, the stone that powers it was grafted onto a Nintendo Power Glove.
Aeon (Channel Awesome - Suburban Knights) crafted a ring made from lodestone that could reflect Malachite's magic back to him.