Some immensely strong and powerful Objects in fictional universes (such as the DC, Marvel, W.I.T.C.H) can grant numerous superpowers to the wielder. Some of these objects are sentient and have a mind and will of their own and can even take full possession of their host's mind and body if the host is in grave danger, or when the host is angered or enraged. These sentient artifacts/objects can even speak through their host when it takes full control over the host's body and mind. The voice of the object depends upon the sex of its chosen host. For example: if the host is female then the voice of the artifact is female, same goes for male. The voice of the artifact is much deeper than its host and even alters his or her personality. Most items are accompanied by Powers Via Object.
The 12 Talismans of Shendu (Jackie Chan Adventures)
The 12 Powerbands (Legend of the Dragon)
Ascalon (Ben 10)
Omega-1 Nanite (Generator Rex)
The Mask of Loki brings the wearer's innermost desires to the surface. (The Mask)
Elements of Harmony (My Little Pony: Friendship is Magic)
The Gem of Amara (Buffy the Vampire Slayer/Angel) renders any vampire who wears it immune to his/her conventional weaknesses.
The Scythe (Buffy the Vampire Slayer)
Several examples of the Shen Gong Wu (Xiaolin Showdown)
The Reality Gauntlet (Danny Phantom)
The Book of Shadows (Charmed)
The First Blade (Supernatural) can kill anything, and is the only known weapon able to kill the Knights of Hell, but is completely useless unless the wielder also possesses the Mark of Cain.
The Colt (Supernatural) can kill any supernatural creature with one shot with the exception of five.
Death's Scythe (Supernatural) is capable of reaping anyone & anything. Angels, demons, reapers, even gods.
The Elder Wand (Harry Potter)
The Gauntlet of Billy. (Adventure Time)
The Heart of Kandrakar. (W.I.T.C.H.)
The Charms of Bezel. (Ben 10)
Jack's sword (Samurai Jack), the only weapon that can truly harm the demon Aku.
The Good Samaritan (Hellboy)
The Eleventh Doctor holding the Sonic Screwdriver (Doctor Who)
The Four Power Stones (Thundercats 2011)
The Meta-Nanites (Generator Rex) are extremely powerful nanites that allow the user control over the fabric of the universe: gravity, matter and energy, time and space, elemental forces, mechanics, etc.
There are a number of stones, crystals, and minerals that used in the construction of light-sabers that yield a variety of results. (Star Wars)
The Phoenix Gate (Gargoyles)
The Eye of Odin (Gargoyles)
The proton packs (Ghostbusters) are the signature weapons of the Ghostbusters.
Hard Drive's Surge Coat (Swat Kats: The Radical Squadron)
The Devo Chamber (Super Mario Bros. film) forces Devolution.
President Koopa later adapted the technology into the portable Devolution Gun.
Lucille (Channel Awesome), also known as the "Hammer of Power", is an ancient artifact disguised as a regular claw-hammer that grants those who are worthy the powers and title of the Blockbuster Buster.
Linkara's Magic Gun (Channel Awesome) is a toy gun that is imbued with powerful magics. Such power comes from the soul of a tortured girl grafted into it by a cult from Silent Hill.
Malachite's Hand (Channel Awesome) was a powerful artifact that grants the user limitless magical power. Because the original gauntlet was old and unfashionable, the stone that powers it was grafted onto a Nintendo Power Glove.
Aeon (Channel Awesome - Suburban Knights) crafted a ring made from lodestone that could reflect Malachite's magic back to him.