Guts, the Blackswordsman (Berserk)
Gildarts Clive (Fairy Tail) uses his Crushing Evil, Spreading the Truth: Empyrean to punch Bluenote all the way up into the highest of skies.
Natsu Dragneel (Fairy Tail) uses his "Fire Dragon King's Demolition Fist" to utterly destroy a God of War.
Majin Boo (Dragon Ball) punches so hard, he blasted Babidi's head clean off.
When his anger it at its most focused, Asura (Asura's Wrath) achieves highest level of power and becomes Mantra Asura.
Monkey D. Luffy (One Piece) is well known for delivering powerful punches with his Gomu Gomu no Pistol.
Megatron: Dark Claw Mode (Transformers: Cybertron)
Optimus Prime: Savage Claw Mode (Transformers: Cybertron)
Kazuma (s-CRY-ed) posses an Alter power that allows him to reconstruct matter over his right arm, forming the matter into a powerful metallic alloy, creating his Shell Bullet and increasing his strength.
He is also capable of increasing his power by using his 'Shell Bullet Ultimate'.
Hitmonchan (Pokemon) about to unleash a powerful Mach Punch.
Jenny Wakeman/XJ-9 (My Life as a Teenage Robot) ready with her Fists of Fury.
Yang (Yin Yang Yo!) with his Paws of Pain.
Heavy (Team Fortress 2) with the Apoco Fists.
Chad (Bleach) can use Brazo Izquierda del Diablo
Subaru Nakajima (Magical Girl Lyrical Nanoha) uses Belka magics in the form of hand-to-hand combat to amplify the strength of her Revolver Knuckle.
True to his name and programming, Ralph (Wreck-It Ralph) is capable of using his powerfully giant hands to wreck anything that gets in his way.
Ganondorf's Warlock Punch carries intense magic force.
Captain Falcon's Falcon Punch carries intense fiery force.
Kamui (Gintama) punching Nobu Nobu so hard he sent the man flying out of the tower.
Kakuzu (Naruto) using Earth Release:Earth Spear to harden his fist to enhance the physical power tremendously.
Night Shift (Skylanders SWAP Force)
Shazam (DC Comics) demonstrating on Superman
The Sentry (Marvel Comics)
Power Man (Marvel Comics)
Iron Fist (Marvel Comics) demonstrates his ability by punching Ragnarok, an evil clone of Thor.
Wonder Man (Marvel Comics)
Spider-Man (Marvel Comics)
Kamala Khan (Marvel Comics)
After sticking it in the Cauldron of Life, Owen Burnett's (Gargoyles) left hand was petrified in the shape of a clenched fist, which he uses to his advantage to deliver powerful punches to his opponents.
Ideo's (One Piece) fists have an incredible destructive power Sugilite can combine both arms and deliver a massive punch
Infernape (Pokémon) using Mach Punch.
Renet (Teenage Mutant Ninja Turtles 2012 TV series)
Wahl Icht (Fairy Tail) while in Assault Mode uses his unique robotic arms to deliver ah struck blows.
Kenshiro (Fist of the North Star)
Falco (Fist of the North Star)
Ein (Fist of the North Star) using Kenka Kenpo (Brawling Martial Arts).
Knuckle the Echidna (Sonic the Hedgehog)
Mister Shifter (Sonic the Comic) attacks Sonic with an enlarged, hardened fist.
The Power Punch Glove (Predator/Aliens vs. Predator) enhances a Predator's punching strength enough to penetrate concrete.
Batman (The Dark Knight) using the Pneumatic Mangler, an arm-mounted device that allows him to cut through or bend metal.
Jonathan Joestar (JoJo's Bizarre Adventure Part I Phantom Blood)
Joseph Joestar (JoJo's Bizarre Adventure Part II Tendency)
The Young Man (Blood Rush) demonstrate his power on some vampire punks.