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User possess extreme or intuitive knowledge and/or skill in using poisons and poisonous substances to harm living beings.
- Enhanced Assassination
- Create poison from other substances.
- Death Inducement
- Necrosis Inducement
- Pain Inducement
- Paralysis Inducement
- Stealth Tactics - possessing skill in concealing poisons.
- Cellular Disintegration
- Chemistry Manipulation
- Disease Manipulation
- Esoteric Toxin Manipulation
- Healing Factor Nullification
- Intuitive Aptitude
- Poison Manipulation
- Users are unable to manipulate poison.
- Users can only create poison from existing sources.
- May accidentally end up poisoning themselves if they do not have Poison Immunity or proper protective gear.
- Sasori (Naruto)
- Kankuro (Naruto)
- The Joker (DC Comics)
- Copperhead (DC Comics)
- Elle Driver (Kill Bill)
- Teemo (League of Legends)