The user is able to overcome the traditional limitations and/or weaknesses of their species as a whole, becoming either more resistant or completely immune to said weaknesses. This can be accomplished through natural evolution or repeated non-lethal exposure to said weakness; for example, a vampire may become immune to sunlight or a werewolf resistance to silver.
In some cases, the user manages to overcome the weaknesses by utilizing specialized equipment or performing special tasks.
Saya Otonashi (Blood+) has been able to control her blood-thirst through regular blood transfusions and eating large quantities of human food.
Goku (Dragon Ball) overcame his weakness to his tail being squeezed through extensive training.
When he still had a tail, Vegeta (Dragon Ball) was able to overcome the Saiyans' traditional weakness of having their tail squeezed.
Alucard (Hellsing) is immune to all vampire weaknesses except the most holy of Christian artifacts, such as Helena's Nail.
After entering Gear Fourth, Luffy (One Piece) is able to retain his natural rubber state despite being coated completely with his Haki which should normally neutralize it, allowing attacks that would normally harm him to simply bounce off.
Due to its unique composition, the Crystal Onix (Pokémon) is immune to water and Water-type attacks, unlike other Onix.
The Frog Hermit (Ranma 1/2) has transcended the limits of his jusenkyo curse, allowing him to talk and fight as if he was still in his human form.
As he was originally human and turned into a vampire, Tsukune Aono (Rosario + Vampire) is unaffected by the traditional vampire vulnerability to water.
In spite of Dio (JoJo's Bizarre Adventure) becoming a vampire, he's immune to almost any weakness, he's only vulnerable to sunlight and Ripple users.
The enhanced Type 2 Las Plagas (Resident Evil) were able to tolerate direct sunlight, though flash grenades were still fatal to them.
Alex Mercer (Prototype) developed an immunity to the anti-Blacklight poison Bloodtox with repeated exposure.
By consuming Rahab's soul, Raziel (Legacy of Kain) was able to overcome his vulnerability to water.
Daurgothoth, the creeping doom (Forgotten Realms) has transcended not only the limits of his undead body, but also the limits of the dragons species as a whole, developing new breath attacks that he shouldn't be able to use, as well as developing other abilities that should be impossible for him because of his undead status.
As he remains God's chosen one despite being a vampire, Gabriel Belmont/Dracula (Castlevania: Lords of Shadow 2) is unaffected by the traditional vampire vulnerability to holy items like crosses, to the extent that he can physically touch one without harm.
Dark Sister (Valkyrie Crusade) is a Vampire that is immune to all of an vampire's weaknesses, such as sunlight and holy powers and objects.
After being implanted with the Mantra Reactor, Asura (Asura's Wrath) is able to freely channel his Wrath Mantra without fear of it backfiring and destroying his body.