The user utilizes a suit of armor that is both composed of high-level science and uses a variety of enchanted materials, or is originally high-tech armor that was subsequently given a permanent enchantment to allow for mystical effects. This combination allows for the utilization of a variety of magical effects, while simultaneously providing the means to interact easily with non-magical technologies. Some versions of this kind of armor may allow the ejection of mystical metals, or even a computer to determine incoming spells and appropriate counter-spells.
The Doom Slayer (Doom 2016) has the Praetor Suit, forged from human technology that was augmented by the demon known at the "wretch."
His Model 37 "Bleeding Edge" Iron Man Armor augmented through dwarven craftsmanship with Uru, Tony Stark/Iron Man (Marvel Comics) was capable of taking on the mystically augmented "Worthy" alongside the others of the "Mighty."
Tony Stark, a.k.a. Iron Man (Marvel Comics) has produced armors composed of elements lethal to certain mystical creatures, such s the Iron Man Armor Model 48 composed of cold iron to fight against dark elves.
First King Xin (Pathfinder) created the clockwork reliquary, meant to house his body and spirit and forged of a variety of different mystical skymetals, though he only was able to use it after becoming undead.
Like some other Skaven (Warhammer), the Warlock-Engineers of Clan Skryre make heavy use of warpstone in their already highly advanced armor.
Chaos Space Marines (Warhammer 40,000) utilize power armor that is often enchanted by the forces of Chaos.
Blessed by Slannesh with mutated power armor, Lucius the Eternal (Warhammer 40,000) utilizes the Armor of Shrieking Souls, which allows him to perform Murderous Possession.
The Grey Knights (Warhammer 40,000) use their Aegis Armor to provide intense protection against the mystical forces on top of the technological benefits of the armor itself.