The ability to be at peak physical and/or mental condition despite being physically handicapped.
The user suffers from some form of physical handicap (missing limbs or eyes, paralysis, terminal illnesses, severe injuries etc.), but said handicap does not hinder them and they remain at peak physical and mental condition.
Johnny Joestar (JoJo's Bizarre Adventure Part VII: Steel Ball Run)
Nagumo Hajime (Arifureta Shokugyou de Sekaisaikyou)
Ramiel (Ange Vierge)
Girge G. Ledo Le Albatross (Broken Blade)
Tsukuyo Inaba (Busou Shoujo Machiavellianism)
Danger Mouse (Danger Mouse)
Edward Elric (Full Metal Alchemist)
Crocodile (One Piece)
Kyros (One Piece)
Shanks (One Piece)
Zeff (One Piece)
Rororna Zoro (One Piece); after time skip
Kuzan (One Piece); after time skip
Eustass Kid (One Piece); after time skip
Future Gohan (Dragon Ball Z)
Majora (Dragon Ball Super)
Alexandra Alshavin/Sasha (Lord Marksman and Vanadis)
Itachi Uchiha (Naruto)
Kimimaro Kaguya (Naruto)
Obito Uchiha/Tobi (Naruto)
Sasuke Uchiha (Naruto)
Ikoma (Kabaneri of the Iron Fortress)
Viper (Kung Fu Panda)
Wolf Boss (Kung Fu Panda)
Armless Sensei (DC Comics)
Legless Sensei (DC Comics)
Barbara Gordon (DC Comics); formerly
Slade Wilson/Deathstroke (DC Comics)
King Snake (DC Comics)
Harvey Dent/Two-Face (DC Comics)
Charles Xavier/Professor X (Marvel Comics); formerly
Maya Lopaz/Echo (Marvel Comics)
Matt Murdock/Daredevil (Marvel Comics)
Toph Beifong (Avatar: The Last Airbender)
Neo (The Matrix)
Ashley J. “Ash” Williams (The Evil Dead series)
Big Boss (Metal Gear)
Kenshi (Mortal Kombat)
River Tam (Firefly)
Montolio Debrouchee/Mooshie (Forgotten Realms)
Jeff "Joker" Moreau (Mass Effect)
Snake Plissken (Escape from New York)
Vanessa Brewer (Angel)
Eli (The Book of Eli)
Zatoichi (The Tale of Zatoichi)
Gildarts (Fairy Tail)
Erza Scarlet (Fairy Tail)
Baiken (Guilty Gear)
Genryūsai Shigekuni Yamamoto (Bleach)
Buzz (Skylanders series)
Anakin Skywalker/Darth Vader (Star Wars)
Luke Skywalker (Star Wars)
Darth Maul (Star Wars)
General Grivous (Star Wars)
Uzu Sanageyama (Kill la Kill)
Gazelle (Kingsman: The Secret Service)
Augus (Asura's Wrath)
Dunban (Xenoblade Chronicles)
Artorias (Dark Souls)
Hiccup Horrendous Haddock III (How to Train Your Dragon)
Gobber the Belch (How to Train Your Dragon)
Carl Grimes (The Walking Dead)
Joe Swanson (Family Guy)
Fizzlepop Berrytwist/Tempest Shadow (My Little Pony: Friendship is Magic)
Various cyborg mobians (Archie's Sonic the Hedgehog)
Atlas (Rising of the Shield Hero)
Hattori Tatsu (Teenage Mutant Ninja Turtles 2012 TV series)
As one of the Yonko, Shanks (One Piece) is one of the most powerful men in the world, and the loss of his left arm did not hinder him in the slightest.
Crocodile (One Piece) makes up for losing his left hand with a massive hook.
Kyros (One Piece) still retains his incredible swordsmanship and agility despite chopping off his own leg.
Sesshomaru (Inuyasha), by his own admission, actually became stronger after losing his left arm to InuYasha.
Big Boss (Metal Gear) was unhindered by the loss of his left eye, and was also able to embark on Operation Snake Eater and successfully complete his mission despite having suffered numerous severe injuries only a week earlier.
Neo (The Matrix) remains a skilled martial artist despite having his eyes cauterized by Smith.
Joker (Mass Effect) is a master pilot despite suffering from severe Vrolik's syndrome in his legs.
Toph Beifong (Avatar: The Last Airbender) is one of the greatest Earthbenders in the world despite being born blind.
Zatoichi (The Tale of Zatoichi) is a supremely skilled swordsman despite being blind.
Despite being paralyzed from the waist down, Joe Swanson (Family Guy) was able to remain on the police force and take down criminals even though being in a wheelchair.
After being render paraplegic by Clock-La, Bentley (Sly Cooper) remains a capable field agent due in part to a high-tech wheelchair.
Despite having his left arm burned off by Sasuke, A (Naruto) was still a challenging ninja.
Even when his arms were incapacitated, Zabuza Momochi (Naruto) killed most of Gato's thugs and Gato with only a kunai in his mouth.
Despite both of his arms being torn off, Deidara (Naruto) was able to hold his own against Team Guy.
After sewing his eyes shut, Uzu Sanageyama's (Kill la Kill) enhanced his senses affinity with his Goku Uniform, allowing him to sense the area all around him, claiming to see the entire world.
Tsukuyo Inaba (Busou Shoujo Machiavellianism) is a blind master swordswoman.
Hiccup Horrendous Haddock III (How to Train Your Dragon), despite missing a leg, is able to accomplish many feats, including his unmatched skills at dragon riding, combat and smithing.
Despite missing an arm and a leg, Gobber the Belch (How to Train Your Dragon) is just as capable of smithing and battle as the rest of his tribe.
Despite born without fangs and have no limbs, Viper (Kung Fu Panda), is able to fight.
Despite her broken horn, Fizzlepop Berrytwist/Tempest Shadow (My Little Pony: Friendship is Magic) is still able to use magic.
Edward Elric (Fullmetal Alchemist)
Bunnie D'Coolette (Archie's Sonic the Hedgehog)
Despite born blind, Hattori Tatsu (Teenage Mutant Ninja Turtles 2012 TV series) has some enhanced senses.
Despite losing his left arm and right eye during the Eclipse, Guts (Berserk) is still a capable swordsman.