Tech E. Coyote (Loonatics Unleashed)
Ami Mizuno (Sailor Moon) possesses an IQ of 300.
Otacon (Metal Gear Solid)
Stewie Griffin (Family Guy) is inhumanly genius, especially for being a one-year old, talking like an adult and creating vast amounts of powerful weapons and other inventions.
Dexter (Dexter's Laboratory) is a boy with an inhumanly high intellect allowing him to build vastly advanced technology
Professor E. Gadd (Super Mario)
Hotaru Imai (Gakuen Alice) with her Invention Alice
Galvans like Grey Matter (Ben 10) are naturally extremely intelligent, and can understand and operate virtually any machine, even if they've never seen it before. Their intelligence also allows them to understand intricate codes and languages.
JJ Powell (No Ordinary Family)
Hunter Rose, the first Grendel, has enhanced intelligence thanks to a brain mutation.
Brainiac (DC) truly lives up to his name..
Bentley's (Sly Cooper) greatest and most primary ability is his intelligence.
The Contessa (Sly Cooper) is highly intelligent who studies criminal psychology.
Sir Raleigh's (Sly Cooper) high intellect serves him as the Fiendish Five's Chief Machinist.
Arpeggio (Sly Cooper) specializes in exotic technology.
Penelope's (Sly Cooper) intellect specializes in machines.
Captain LeFwee (Sly Cooper) intellect is rivaled with Bentley's.
Dr. M (Sly Cooper) is an extremely intelligent foe; easily on the scale of Bentley and Clockwerk.
Master Yao (Legends of Awesomeness) is a legendary kung fu master renowned by many for his outstanding intellect; among his admirers is Shifu, who idolizes him and once commented on Yao being "the greatest kung fu mind this world has ever known".
Shiro (No Game No Life) has genius-level intellect, she can speaks 18 languages, and learned to read Imanity in 15 minutes.
While not as intelligent as Shiro, Sora (No Game No Life) is shown to have a brilliant IQ.
Jibril (No Game No Life) live for six millennia, therefore, her knowlege is outstanding when compared to others.
Donatello (Teenage Mutant Ninja Turtles)
Doctor Ivo "Eggman" Robotnik (Sonic the Hedgehog) possesses an IQ of 300.
Miles "Tails" Prower (Sonic the Hedgehog)
Wave the Swallow (Sonic the Hedgehog)
Blossom (The Powerpuff Girls)
Mojo Jojo (The Powerpuff Girls)
Sheldon (Splatoon) describes himself as has an above-average intellect, which helps when it comes to creating weapons based on his late "Grandpappy's" blueprints.
Brains's (Thunderbirds) intellect is what made the thunderbird machines possible.
Pongo (101 Dalmatians) is abnormally intelligent for his kind, being able to tell human time, operate a computer and come up with various plans to outwit Cruella and her henchmen.
Cadpig (101 Dalmatians) is unusually intelligent for her age, being able to speak in "metaphysical metaphors" and displaying an extensive knowledge of (fictional) tribes and cultures.
Among other properties, Metebelis crystals (Doctor Who) could enhanced one's intelligence
Ryder's intellect (PAW Patrol) has allowed him to create various gadgets for the PAW Patrol
Davros (Doctor Who) is a brilliant, but insane scientist
Lex Luthor (DC Comics) is one of the greatest intellectuals in the DC Universe, achieving such feats as solving the Anti-Life Equation.
As his name implies, Brain (Pinky and The Brain) is highly intelligent
Viras (Gamera vs Viras) possesses an IQ of 2500
Despite their feral appearance, Mirelurks (Fallout) are highly intelligent.
The Velociraptors of Jurassic Park (Jurassic Park series) are smarter than primates.
Egghead (DC Comics) is stated to be the second smartest crimmal mind in the world.