Igor Planter (Black Cat) using Tao to control and become plant-life, but he overdosed on the potion that gave him power, killing him.
Gyanza Rujike (Black Cat) using his Tao to enhance his muscles, but due to his lack of training on how to use his ki efficiently, he ended up depleting his life force from overuse and dying.
Those who contract Est (Bladedance of Elementalers) will grant enormous power, but the side effect is when she slay spirits, it passes on the curses and resentment of the sprits slain by her onto her master, and eventually taking the user's life in exchange.
Kokujō Tengen Myō'ō (Bleach) possesses immense physical strength due to its size, but that large size makes is a bigger target, and any damage inflicted will be reflected on its user, Komamura. Komamura's main concept of his Bankai is to utilize its immense destructive force before the opponent can cause any harm in return.
Kokujō Tengen Myō'ō: Dangai Jōe gains the power of immortality and increased agility, but it came at the cost of Komamura offering his physical heart to transform into a human, which when worn off, transformed him into a wolf who only thirsted for revenge.
Ichigo Kurosaki (Bleach) becoming one with Zangetsu and his Inner Hollow for the Final Getsuga Tensho, which would deprive him of his Shinigami powers after.
Giriko Kutsuzawa (Bleach) can use his Time Tells No Lies to set contracts with the God of Time, but cannot undo it once it is set, and even himself can be affected by the Flames of Time if the contract is broken.
Rei (Code: Breaker) can control the seven flames of hell, at the cost of something, such as his sense of taste and one of his organs.
Arale Norimaki (Dr. Slump) using her signature N'cha Cannon, firing a powerful beam from shouting a greeting, but it is very draining on her power reserves, repeated usage will result her ceasing to function until recharge.
In the Great Ape form, a Saiyan's (Dragon Ball) power level increases tenfold, but without the proper training, they lose their sense of reason, being reduced to mindless beasts.
Ultimate Shenron (Dragon Ball GT) can grant any wish without restriction, but if the Black Star Dragon Balls are not returned to the place of his last summoning within a year's time, the planet on which he was summoned will explode.
Through the usage of the Kaioken, Goku (Dragon Ball Z) can increase his speed, strength, and senses, but multiplying the intensity beyond what he can handle can damage his body and potentially kill him.
Frieza's (Dragon Ball Z) 100% Full Power grants him power, but with the strain on his body, he is not able to fight at maximum capacity for long, slowly weakening.
Frieza's Golden form (Dragon Ball Z) grants vast power, but quickly expends his stamina.
Tenshinhan (Dragon Ball) using the Kikoho to cause massively powerful strikes, but it is very draining on his life-force, and repeated usage will eventually kill him.
When Trunks (Dragon Ball Z) uses Super Saiyan Third Grade, it grants him strength and power, but the massive muscle increase inhibits his speed.
Guldo (Dragon Ball Z) can freeze time, but it only lasts as long as he can hold his breath, and expends a lot of his energy.
Kyouka (Fairy Tail) can increase the powers of those she targets, if they are not strong enough, she turns them into small paper like figures.
When Ultear Milkovich (Fairy Tail) uses the ultimate arc of time magic Last Ages she can rewind time for the entire planet, but in exchange she gives up all her remaining life, completely burning out all the magic in her body and rapidly ageing her into an old woman.
After their failed attempt at bringing their mother back to life, Edward and Alphonse Elric (Fullmetal Alchemist) suffered the backlash of the "Law of Equivalent Exchange," costing Ed his right arm and left leg and Al his entire physical body.
A dangerous technique from the Ancient Martial Arts, Seidou Goei (History's Strongest Disciple Kenichi) combines the opposing ki of Sei and Dou, by having the first being focused inward, while having the second explode outward. However due to the conflicting nature of the ki of Sei and Dou, extensive use of this technique causes a disruption in one's flow of ki resulting in crippling, even fatal damage to the user.
Miroku's (InuYasha) Wind Tunnel can devour everything, but it grows in size every year or from damages to the sides, eventually sucking himself in, resulting in death. Also, any poison he sucks in will injure him.
In his full-demon form, InuYasha (InuYasha) possesses great power, but his demon blood begins to eat away at his sanity and human soul.
Megumin (Konosuba) has mastered the Explosion spell to the absolute exclusion of any other magic, unfortunately she can only cast it once a day as it completely drains all her magic reserves, leaving her completely helpless and immobile.
Refal (Legend of the Legendary Heroes) wields Glouvil a massive sword with immense destructive power, but in order to unleash this power he must sacrifice something of himself every time its power is used.
Denki Kaminari (My Hero Academia) possesses the quirk "Electrification", allowing him to generate electricity
from his body. However, exceeding his wattage limit would short circuit his brain, leaving him temporarily brain dead for an hour.
Having inherited the quirk "One For All" from All Might, Izuki Midoriya (My Hero Academia) is able to stockpile and harness power...
...allowing him to perform physical feats unrivaled by any other quirk-user...
...but do to a lack of control and a feeble body, the power could strain his body to the point that it would break whatever part of the body he used.
Minoru Mineta (My Hero Academia) possesses the quirk "Pop Off", allowing him to remove sticky balls from his head and place them on any surface. Should he do this too much, he eventually starts to bleed.
Hanta Sero (My Hero Academia) possesses the quirk "Tape", allowing him to eject strips of tape from his elbows. Overuse of this ability eventually leads to dry skin.
Tetsutetsu Tetsutetsu (My Hero Academia) possesses the quirk "Steel", allowing him to turn his body into pure steel. Use of this however causes iron fatigue, eventually weakening his form.
Thirteen (My Hero Academia) has the power to generate black holes
. However, the black holes created are incredibly unstable and could cause immense damage if not regulated properly.
Shouto Todoroki (My Hero Academia) possesses the quirk "Half-Cold Half-Hot" gives the right side of his body the power to generate ice
and his left side to generate fire
. Overuse of one specific power could be detrimental to his body and weaken his attacks, such as the overuse of his ice powers giving him frostbite.
...the darker it is, the more savage and uncontrollable it becomes.
...causes her to feel severe nausia.
The Akimichi Three-Colored Pills (Naruto) converts calories into chakra to make it easier to use their calorie control abilities, but are poisonous and the conversion leaves the user potentially lethally emaciated.
Might Guy (Naruto) using the Night Guy technique after opening the eighth inner gate, which was a move so powerful, it ultimately ended his ninja career as the bones in his right leg were damaged to the point where it could never be fully healed, leaving Guy as a paraplegic even though Naruto used his new healing powers to save Guy's life before his body turned to ash.
Kakashi Hatake (Naruto), being a non-Uchiha, will suffer even more stress from the Mangekyo Sharingan than any Uchiha using it.
Mizuki (Naruto) using an experimental cursed seal that gave him animal traits with explosive power, but the strain destroyed his cells and nearly killed him.
The more Itachi Uchiha (Naruto) uses is Mangekyo Sharingan, the more his eyesight will deteriorate.
Sasuke Uchiha (Naruto) activating the Cursed Seal of Heaven to gain an increase in chakra and power, but extended usage will corrode his mind from Orochimaru's, causing him to go mad.
In his four-tailed form and onwards, Naruto Uzumaki (Naruto) possesses great strength, but the Nine-Tailed Fox's chakra constantly destroys and regenerates his skin, shortening his life.
Overtaking the Rumble Ball (One Piece) can cause Chopper's transformation to go haywire, and even force him to expend his life force. After the timeskip he only needs one Rumble Ball to enter his Monster Point, and while he can now control himself, it still expends his life force requiring rest afterwards.
The Energy Steroids (One Piece) doubles the user's power temporarily, but accelerates their aging per pill.
Luffy's Gear Second (One Piece) increases his strength and speed, but causes strain on his body and potentially shortens his lifespan.
Luffy's Gear Fourth: Bounceman (One Piece), may greatly enhance his strength and speed similar to what both Gear Second or Gear Third individually grants, but it also overuses his Busoshoku Haki, leaving him temporarily unable to use it for a set period of time once he reaches his limit, and can also leave Luffy exhausted after it wears off.
Despite the advantage of being able to cancel out other Devil Fruit users' powers via physical contact, Marshall D. Teach (One Piece) is more susceptible to pain than anyone else because of the gravity-based nature of the Yami Yami no Mi of drawing things in, which is the fruit's only notable weakness, even though is classified as a Logia.
Using Meteoric Burst, Boros (One-Punch Man) boosts his capabilities beyond their limits, but doing so fatigues his body and potentially shortens his lifespan.
When Pryce (Pokemon Adventures) forced Celebi to travel back in time, it adversely caused temperature dropping to absolute zero and the world completely freezing.
In her Iron Maiden form, Ruby Tojo (Rosario + Vampire) has great magical power, but the more she moves, the more the suit tightens around her body, causing physical damage.
In his Ghoul form, Tsukune Aono (Rosario + Vampire) possesses great vampiric powers, but at the cost of his sanity.
Yukishiro Enishi (Rurouni Kenshin) using his Frenzied Nerves to greatly amplify his five senses and reflexive speed, but it causes him to discard defense in exchange.
Kazuma (s-CRY-ed) is able to use his Shell Bullet Ultimate, but the cost of straining his right arm to the point where all feeling is lost.
Usagi Tsukino better known as Sailor Moon (Sailor Moon) with Legendary Silver Crystal tremendous power, capable of reviving an entire world from ruin but the strain of using such power often costs the user her life - as the power actually derives from the life force of the Moon dynasty, the members of which alone can actually use it.
Sailor Saturn (Sailor Moon) is the Sailor Soldier of Silence and Destruction. She uses her planetary weapon, the Silence Glaive, to utterly destroy entire worlds and planets. However doing so will kill her as well.
Ruki (Senyu) can create dimensional portals that can transport anyone anywhere, but doing so will cause the targets ribs to break every time.
When in Mover Mode, Cosmo's species (Sonic X) obtain vast power, but it causes them to expend their life force, and extensive usage is fatal.
Younger Toguro (Yu Yu Hakusho) gets terribly hungry in his 100% form, requiring him to instinctively absorb souls constantly to maintain his form.
Younger Toguro (Yu Yu Hakusho) forcing himself past his 100%, reaching 120%, which led his body to ultimately break down from strain.
Riou’s (Zatch Bell!) curse allows him to drain people’s life energy. However using the curse, puts great strain on Riou’s body, especially if used on many people.
Darkness ÄRM (Marchen Awakens Romance) allow the user to perform curses, but many of these ÄRM come with risky side effects.
Saitama (One Punch Man) gained access to virtually unlimited power after breaking his natural limiter by going through a brutal training regime for three whole years, but at the cost of his hair and his ability to feel emotions.
Garou (One Punch Man) had also started to break his own limiter just like Saitama, and as a result was starting to lose his humanity and became a monster.