Igor Planter (Black Cat) using Tao to control and become plant-life, but he overdosed on the potion that gave him power, killing him.
Gyanza Rujike (Black Cat) using his Tao to enhance his muscles, but due to his lack of training on how to use his ki efficiently, he ended up depleting his life force from overuse and dying.
Those who contract Est (Bladedance of Elementalers) will grant enormous power, but the side effect is when she slay spirits, it passes on the curses and resentment of the sprits slain by her onto her master, and eventually taking the user's life in exchange.
Kokujō Tengen Myō'ō (Bleach) possesses immense physical strength due to its size, but that large size makes is a bigger target, and any damage inflicted will be reflected on its user, Komamura. Komamura's main concept of his Bankai is to utilize its immense destructive force before the opponent can cause any harm in return.
Kokujō Tengen Myō'ō: Dangai Jōe gains the power of immortality and increased agility, but it came at the cost of Komamura offering his physical heart to transform into a human, which when worn off, transformed him into a wolf who only thirsted for revenge.
Ichigo Kurosaki (Bleach) becoming one with Zangetsu and his Inner Hollow for the Final Getsuga Tensho, which would deprive him of his Shinigami powers after.
Giriko Kutsuzawa (Bleach) can use his Time Tells No Lies to set contracts with the God of Time, but cannot undo it once it is set, and even himself can be affected by the Flames of Time if the contract is broken.
By drawing on their Yoki, Claymores (Claymore) can become more and more powerful at the risk of becoming monstrous Awakened Beings…
…as was the fate of Priscilla.
Rei (Code: Breaker) can control the seven flames of hell, at the cost of something, such as his sense of taste and one of his organs.
Bai like all Contractors, (Darker than Black) must fulfill his/her task after using their powers
Arale Norimaki (Dr. Slump) using her signature N'cha Cannon, firing a powerful beam from shouting a greeting, but it is very draining on her power reserves, repeated usage will result her ceasing to function until recharge.
In the Great Ape form, a Saiyan's (Dragon Ball series) power level increases tenfold, but without the proper training, they lose their sense of reason, being reduced to mindless beasts.
Tenshinhan (Dragon Ball series) using the Kikoho to cause massively powerful strikes, but it is very draining on his life-force, and repeated usage will eventually kill him.
Ultimate Shenron (Dragon Ball GT) can grant any wish without restriction, but if the Black Star Dragon Balls are not returned to the place of his last summoning within a year's time, the planet on which he was summoned will explode.
Through the usage of the Kaioken, Goku (Dragon Ball series) can increase his speed, strength, and senses, but multiplying the intensity beyond what he can handle can damage his body and potentially kill him.
The Ultra Instinct transformation gives Goku (Dragon Ball series) incredible power…
…but its usage eventually caused his body to begin to break down, causing heavy bleeding…
Guldo (Dragon Ball series) can freeze time, but it only lasts as long as he can hold his breath, and expends a lot of his energy.
Frieza's (Dragon Ball series) 100% Full Power grants him power, but with the strain on his body, he is not able to fight at maximum capacity for long, slowly weakening.
Frieza's Golden form (Dragon Ball series) grants vast power, but quickly expends his stamina.
When Trunks (Dragon Ball series) uses Super Saiyan Third Grade, it grants him strength and power, but the massive muscle increase inhibits his speed.
Kyouka (Fairy Tail) can increase the powers of those she targets, if they are not strong enough, she turns them into small paper like figures.
When Ultear Milkovich (Fairy Tail) uses the ultimate arc of time magic Last Ages she can rewind time for the entire planet, but in exchange she gives up all her remaining life, completely burning out all the magic in her body and rapidly ageing her into an old woman.
Rasen (Flame of Recca) can use the Kōkai Gyoku to erase anything in existence, whether it be physical, mental, or conceptual. In exchange, it takes something of equal value from the user.
After their failed attempt at bringing their mother back to life, Edward and Alphonse Elric (Fullmetal Alchemist: Brotherhood) suffered the backlash of the "Law of Equivalent Exchange," costing Ed his right arm and left leg and Al his entire body.
Dangerous technique from the Ancient Martial Arts, Seidou Goei (History's Strongest Disciple Kenichi) combines the opposing ki of Sei and Dou by focusing the first inward and having the second explode outward.Due to the conflicting nature of the Sei and Dou, extensive use of this technique causes disruption inflow of ki resulting in crippling, even fatal damage.
Miroku's (Inuyasha) Wind Tunnel can devour everything, but it grows in size every year or from damages to the sides, eventually sucking himself in, resulting in death. Also, any poison he sucks in will injure him.
In his full-demon form, InuYasha (Inuyasha) possesses great power, but his demon blood begins to eat away at his sanity and human soul.
While using his Wind Suit technique, Wamuu (JoJo's Bizarre Adventure Part II Battle Tendency) wraps himself in a whirlwind of steam giving him the ability to reflect the sun's rays off his body but only lasting for roughly ten seconds, which forces Wammu to stay near a sheltered area, in order to take cover once the technique is over…
…and his Atmospheric Rift, which also uses the tubes for his Wind Suit, can gather huge amounts of air and compresses it in his lungs, however, it slowly tears his body apart given the scraping and heat led by the quick wind compression.
Stands (JoJo's Bizarre Adventure) can grant advantages, however, any damage inflicted on a Stand will be reflected on their user.
DIO's Stand, The World, (JoJo's Bizarre Adventure) can stop time but only for five seconds, however, in spite of his immortality increasing its power, time would stop for about nine seconds.
Megumin (Konosuba) has mastered the Explosion spell to the absolute exclusion of any other magic, unfortunately she can only cast it once a day as it completely drains all her magic reserves, leaving her completely helpless and immobile.
Refal (Legend of the Legendary Heroes) wields Glouvil a massive sword with immense destructive power, but in order to unleash this power he must sacrifice something of himself every time its power is used.
Darkness ÄRMs (Marchen Awakens Romance) allow the user to perform curses, but many of these ÄRMs come with risky side effects.
Unlike a true ÄRM which chooses to be partners with its user, Ghost ÄRMs (Marchen Awakens Romance) gradually eat away at their user's life energy.
After receiving critical injuries during his fight with All For One, All Might (My Hero Academia) can only use One For All for three hours straight…
…causing him to revert back to his original appearanc, and any longer would strain his body as well as shorten the time limit on his Quirk if he's forced to use it as a repercussion.
Denki Kaminari (My Hero Academia) possesses the quirk "Electrification", allowing him to generate electricity
from his body. However, exceeding his wattage limit would short circuit his brain, leaving him temporarily brain dead for an hour.
Having inherited the quirk "One For All" from All Might, Izuki Midoriya (My Hero Academia) is able to stockpile and harness power…
…allowing him to perform physical feats unrivaled by any other quirk-user…
…but do to a lack of control and a feeble body, the power could strain his body to the point that it would break whatever part of the body he used.
Minoru Mineta (My Hero Academia) possesses the quirk "Pop Off", allowing him to remove sticky balls from his head and place them on any surface. Should he do this too much, he eventually starts to bleed.
Hanta Sero (My Hero Academia) possesses the quirk "Tape", allowing him to eject strips of tape from his elbows. Overuse of this ability eventually leads to dry skin.
Tetsutetsu Tetsutetsu (My Hero Academia) possesses the quirk "Steel", allowing him to turn his body into pure steel. Use of this however causes iron fatigue, eventually weakening his form.
Thirteen (My Hero Academia) has the power to generate black holes
. However, the black holes created are incredibly unstable and could cause immense damage if not regulated properly.
Shouto Todoroki (My Hero Academia) possesses the quirk "Half-Cold Half-Hot" gives the right side of his body the power to generate ice
and his left side to generate fire
. Overuse of one specific power could be detrimental to his body and weaken his attacks, such as the overuse of his ice powers giving him frostbite.
…the darker it is, the more savage and uncontrollable it becomes.
Ochako Uraraka (My Hero Academia) quirk "Zero Gravity", allows her to alter the gravitational weight
of anyone or anything she touches. however…
…overuse causes her to feel severe nausea.
The Akimichi Three-Colored Pills (Naruto) converts calories into chakra to make it easier to use their calorie control abilities, but are poisonous and the conversion leaves the user potentially lethally emaciated.
Might Guy (Naruto) using the Night Guy technique after opening the eighth inner gate, which was a move so powerful, it ultimately ended his ninja career as the bones in his right leg were damaged to the point where it could never be fully healed, leaving Guy as a paraplegic even though Naruto used his new healing powers to save Guy's life before his body turned to ash
Kakashi Hatake (Naruto), being a non-Uchiha, will suffer even more stress from the Mangekyo Sharingan than any Uchiha using it.
Mizuki (Naruto) using an experimental cursed seal that gave him animal traits with explosive power, but the strain destroyed his cells and nearly killed him.
The more Itachi Uchiha (Naruto) uses is Mangekyo Sharingan, the more his eyesight will deteriorate.
Sasuke Uchiha (Naruto) activating the Cursed Seal of Heaven to gain an increase in chakra and power, but extended usage will corrode his mind from Orochimaru's, causing him to go mad.
In his four-tailed form and onwards, Naruto Uzumaki (Naruto) possesses great strength, but the Nine-Tailed Fox's chakra constantly destroys and regenerates his skin, shortening his life.
Kuro (One Piece) can move at blinding speed, however, he can't clearly see who he attacks, given said, his remorseless towards his crew says otherwise.
Overtaking the Rumble Ball (One Piece) can cause Tony Tony Chopper's Devil Fruit powers to go haywire, and even force him to expend his life force. After the timeskip he only needs one Rumble Ball to enter his Monster Point, and while he can now control himself, it still expends his life force requiring rest afterwards.
Before mastering it, Monkey D. Luffy's (One Piece) Gear Second technique would increase his strength and speed, but cause immense strain on his body and potentially shorten his lifespan…
…and Gear Third - Bone Bullon, which increases his strength, however, brings about shrinking upon deactivation…
…and while using Gear Fourth - Bounceman, which greatly enhances his strength and speed similar to what both Gear Second or Gear Third individually grant, but it also overuses his Busoshoku Haki, leaving him temporarily unable to use it for ten minutes once he reaches his limit, and also immensely taxes his body and stamina, leaving him exhausted and barely able to move after it wears off.
Despite the advantage of being able to cancel out other Devil Fruit powers via physical contact, Marshall D. Teach (One Piece) is more susceptible to pain than anyone else because of the gravity-based nature of the Yami Yami no Mi of drawing things in, which is the fruit's only notable weakness, even though is classified as a Logia.
The Mink Tribe (One Piece) Tsulong transformation grants them undesputed power and fighting ability during the fullmoon, at the cost of higher brain function and they're stamina. Running the risk of burning out their life force if activated for too long.
Capone Bege (One Piece) feels any damage done to him in his Big Father form and should it be destroyed, he will die.
Using Meteoric Burst, Boros (One-Punch Man) boosts his capabilities beyond their limits, but doing so fatigues his body and potentially shortens his lifespan.
Garou (One Punch Man) had also started to break his own limiter just like Saitama, and as a result was starting to lose his humanity and became a monster.
Saitama (One Punch Man) gained access to virtually unlimited power after breaking his natural limiter by going through a brutal training regime for three whole years, but at the cost of his hair, his ability to feel emotions (somewhat) and suffering chronic unotability in spite of his impressive strength.
When Pryce (Pokémon Adventures) forced Celebi to travel back in time, it adversely caused temperature dropping to absolute zero and the world completely freezing.
In her Iron Maiden form, Ruby Tojo (Rosario + Vampire) has great magical power, but the more she moves, the more the suit tightens around her body, causing physical damage.
In his Ghoul form, Tsukune Aono (Rosario + Vampire) possesses great vampiric powers, but at the cost of his sanity.
Yukishiro Enishi (Rurouni Kenshin) using his Frenzied Nerves to greatly amplify his five senses and reflexive speed, but it causes him to discard defense in exchange.
Kazuma (s-CRY-ed) is able to use his Shell Bullet Ultimate, but the cost of straining his right arm to the point where all feeling is lost.
Usagi Tsukino better known as Sailor Moon (Sailor Moon) with Legendary Silver Crystal tremendous power, capable of reviving an entire world from ruin but the strain of using such power often costs the user her life - as the power actually derives from the life force of the Moon dynasty, the members of which alone can actually use it.
Sailor Saturn (Sailor Moon) is the Sailor Soldier of Silence and Destruction. She uses her planetary weapon, the Silence Glaive, to utterly destroy entire worlds and planets. However doing so will kill her as well.
Ruki (Senyu) can create dimensional portals that can transport anyone anywhere, but doing so will cause the targets ribs to break every time.
When in Mover Mode, Cosmo's species (Sonic X) obtain vast power, but it causes them to expend their life force, and extensive usage is fatal.
Younger Toguro (Yu Yu Hakusho) gets terribly hungry in his 100% form, requiring him to instinctively absorb souls constantly to maintain his form….
…and if forcing himself past his 100%, reaching 120%, which led to his body to ultimately break down from strain.
Riou’s (Zatch Bell!) curse allows him to drain people’s life energy. However using the curse, puts great strain on Riou’s body, especially if used on many people.
When Jean Pierre Polnareff's Stand, Silver Chariot, (JoJo's Bizarre Adventure Part III Stardust Crusaders) removes its armor, it increases its speed, though makes it more vulnerable to attacks.