Stan Smith (American Dad!) wielding a Heaven Gun he took from an angel bailiff.
Issei Hyodou (Highschool DxD) wielding the divine sword Ascalon.
Izanagi and Izanami (Japanese Mythology) used the Spear of Creation to create the world.
Pit (Kid Icarus) armed with the Three Sacred Treasures: the Mirror Shield, the Arrows of Light, and the Wings of Pegasus.
Kurohime (Magic User Kurohime) wielding the Ultimate Sword, which contains the four Spirit Kings, and possesses so much power that it can cut through anything, even the Six High Gods and an entire planet.
Thor (Marvel) wields Mjolnir, a powerful hammer that possesses great durability, the ability to absorb energy as well project it, and a Worthiness Enchantment that allows it to be wielded only by him.
Itachi Uchiha's Susanoo (Naruto) can summon the holy sealing, Totsuka no Tsurugi, which is capable of sealing anything it pierces.
Obito Uchiha (Naruto) forming the holy sword, Nunoboko no Tsurugi, out of the Ten-Tails' chakra.
The Spear of Longinus (Neon Genesis Evangelion) can pierce all A.T. Fields, and is instrumental in the Instrumentality of Mankind.
Ryu Hayabusa (Ninja Gaiden) possesses the Dragon Sword, a weapon carved from the fangs of one the Divine Dragon Deities and infused with its power. The sword can only be wielded by the strongest and most spiritually pure of mankind. Once combined with Eye of the Dragon, it becomes the True Dragon Sword, possessing unrivaled power that is capable of upsetting the balance of the world.
Odin's (Norse Mythology) mighty spear, Gungnir, never misses its target.
Panty and Stocking (Panty and Stocking with Garterbelt) are able to transform their garments into powerful weapons, Backlace, and Stripe I and II respectively, that possess the abilities to blast and cut ghosts, demons, and angels.
Jack (Samurai Jack) possesses a magic sword that forged by the deities Odin, Ra, and Vishnu, and powered by the righteousness and Qi of his father. The sword is capable of cutting through any mundane substance as well as destroy any evil it comes in contact with.
Siegfried Schtauffen (Soul series) is one of the wielders of Soul Edge, the powerful holy sword created to destroy Soul Edge. With Soul Edge in his possession, Siegfried can summon numerous ice crystals, use the crystals to create armor around him, and use its power to combat Soul Edge's demonic force.
In many incarnations, Link (The Legend of Zelda) often wields the Master Sword. Blessed by the Goddess, Hylia, the blade possesses the abilities to repel evil, protect its user from corruption, absorbing energy in various forms, and possesses a mystical link that allows it to only be wielded by those who posses the soul of the goddess's chosen hero.
The Phantom Sword (The Legend of Zelda) is a holy weapon that can take down phantoms and the evil Bellum.
Seraph blades (The Shadowhunter Chronicles) can be used by Shadowhunters to fight Demons and Downworlders.
Alec Lightwood (The Shadowhunter Chronicles) shoots arrows inscribed with angelic runes.
Queen Arthur (Valkyrie Crusade) wields a holy sword.
Destroyer (Valkyrie Crusade) is a divine weapon itself,she is the Celestial Realm's ultimate weapon and is an unstoppable force.
Durandal (Valkyrie Crusade) is a goddess that possess a holy sword that can cut through anything.
Longinus (Valkyrie Crusade) wields the holy spear Longinus,that can destroy deities.
Excalibur (Valkyrie Crusade) wields the sacred sword excalibur.
Gungnir (Valkyrie Crusade)
Mjolnir (Valkyrie Crusade)
Arch Knight (Valkyrie Crusade) is a young girl who possess an ancient divine weapon of the gods.
Emi Yusa (The Devil is a Part-Timer!) wields Better Half, a holy sword crafted from heavenly metal that can only be used by a human-angel hybrid.
The Barbed Cross (Infamous: Festival of Blood) is a holy relic specifically designed to combat vampires and other creatures of the night, forged from silver, submerged in holy water, and blessed by God Himself.