Gordon (Agents of S.H.I.E.L.D.) lost his eyes as a result of undergoing Terrigenesis to activate his powers.
Despite being blind, Toph Beifong (Avatar: The Last Airbender) is capable of "seeing" by sensing vibrations.
After losing his sense of touch, Peyton Westlake's (Darkman) body overproduces adrenaline, granting him superhuman strength and immunity to pain.
Having been deliberately raised to interpret body language as a first language, Cassandra Cain (DC Comics) is illiterate and barely able to speak, but as a trade-off, she can intuitively read body language and predict her opponents' attacks.