The black flames of Amaterasu (Naruto) are inextinguishable, and are so deadly that they won't stop until they burn down everything to ashes.
Obito's Yin-Yang weapons can cause anything but senjutsu to cease to exist.
Dust Release are techniques that destroy matter and energy at a molecular level.
Mard Geer (Fairy Tail) can use the Memento Mori that is the ultimate curse, erasing one's existence for eternity by removing life and death.
Ichibē Hyōsube (Bleach) using Futen Daisatsuryō to completely destroy his foes with blackness, that not even their souls can reincarnate.
Jabberwock (Project ARMS) is an engine of destruction, with deadly abilities such as raising temperature, electromagnetic railgun, hypersonic vibration, and the deadliest is antimatter production.
King Chicken (Duckman) created the Beautex virus, which eats away matter, causing it to devolve through its various stages and then banishing it into nowhere, causing the world to nearly vanish completely.
Dr. Ivo Robotnik (Sonic the Hedgehog) preparing his Ultimate Annihilator, a satellite cannon that can utterly erase matter from reality.
Kosuke setting off an Implosion BIM that can shave off all matter via its vacuum explosion.
Bender Bending Rodríguez (Futurama) wielding the Planetary Annihilator, which fires a deadly beam with an ever expanding diameter that annihilates all matter.
The Azure Flame (Code: Breaker) will burn everything to nothingness.
Negation (Code: Breaker) from Pandora's Box is capable of destroying the world outright.
Train Heartnet (Black Cat) firing an Orichalcum bullet out of Hades, which is capable of destroying any material on Earth.
Accelerator's (A Certain Magical Index) vector manipulating abilities have immense destructive potential, capable of wrecking the planet.
Hirose Yuichi's (Alive: The Final Evolution) power, Void, destroys any and all matter it hits.
When Peter Griffin and Ernie (Family Guy) fights, the two always cause massive destruction and many casualties.
According to the mural, Chaos (Sonic the Hedgehog) is the "God of Destruction", and will destroy the entire world by flooding it.
Solaris (Sonic the Hedgehog) can consume all timelines, and in turn, cause time itself to collapse, and all reality to be destroyed.
Dark Gaia (Sonic the Hedgehog) lives up to his role to destroy, and creates fissures across the entire Earth, literally splitting the planet to pieces.
Time Eater (Sonic the Hedgehog) tearing through space and time to reduce everything to a "White Space".
Tabuu (Super Smash Bros Brawl) tries to destroy the entire world of trophy.
Anything the edge of Zanka no Tachi (Bleach) touches is eradicated into nothingness.
Blackbeard's (One Piece) Yami Yami no Mi reduces all to nothing, while his Gura Gura no Mi destroys all.
Sailor Saturn (Sailor Moon) is the Sailor Soldier of Silence and Destruction. She uses her planetary weapon, the Silence Glaive, to utterly destroy entire worlds and planets.
Miroku (InuYasha) can destroy anything he sucks into his Kazaana.
Flandre Scarlet (Touhou Project) is a vampire with the power to crush the energy center ("eye") of anything in her hand, instantly destroying it.
Galactus (Marvel Comics) using the Power Cosmic.
The Infinity Gems (Marvel Comics) was proven to be highly destructive when Thanos was using it.
The Phoenix Force (Marvel Comics)
The Living Tribunal (Marvel Comics) only answers the One-Above-All.
The Goblin Force (Marvel Comics)
The Ultimate Nullifier (Marvel Comics)
Captain Atom destroys his self-created Universe
The Ogdru Jahad are destined to bring about the apocalypse.
When possessed by the Phoenix Force, Jean Grey (Marvel Comics) is strong enough to destroy everything at a molecular level.
Beerus (Dragon Ball Z: Battle of Gods), as the God of Destruction, is powerful enough to annihilate entire galaxies.
All memory of your existence will be wiped from reality. You will die, and no one will mourn.
Ryner (Legend of the Legendary Heroes) is able to analyze and destroy existence.
Izayoi Sakamaki (Problem Children are Coming from Another World, Aren't They?)'s gift is Code: Unknown, allow him to destroy anything, even gifts.
Harihara (Valkyrie Crusade) the goddess of creation and destruction.
Ate (Valkyrie Crusade) the goddess of ruin and delusion.
Angra Mainyu (Valkyrie Crusade)
The Darkness (Supernatural) had previously destroyed each world God created, leading to his decision to bind and lock her away
Clear Note’s (Zatch Bell) spells focus on completely annihilating his opponents. Clear wants to become the mamodo king solely so he can bring genocide to his world. He even believes the destruction of his kind was the very reason he was born.