The power to unmake and destroy anything, everything and everyone to total and utter nothingness. Opposite to Creation.
User can destroy/annihilate into total and utter nothingness anything, everything and everyone, beginning with entire areas, buildings, cities, countries, states, continents, worlds, planets, dimensions, inter-dimensions, parallel worlds, solar systems, stars, star systems, whole entire galaxies nebula's and universes and possibly even abstract concepts and/or natural forces/laws.
Cosmic and high-level possessors of this immeasurably limitless god-like ability can literally go beyond space-time itself, thus wiping out and destroying all that exists in the entire universe and way beyond.
Illudium PU-36 Explosive Space Modulator (Looney Tunes - Hare-Way to the Stars)
The M'Kraan Crystal (Marvel Comics)
Kuzusu Atom (Xiaolin Showdown)
Alien X (Ben 10)
Galactus (Marvel Comics) using the Power Cosmic.
The Infinity Gems (Marvel Comics) was proven to be highly destructive when Thanos was using it.
The Phoenix Force (Marvel Comics)
The Living Tribunal (Marvel Comics) only answers the One-Above-All.
Abraxas (Marvel Comics)
The Goblin Force (Marvel Comics)
The Ultimate Nullifier (Marvel Comics)
When possessed by the Phoenix Force, Jean Grey (Marvel Comics) is strong enough to destroy everything at a molecular level.
Captain Atom (DC Comic) destroys his self-created Universe
The Ogdru Jahad (Hellboy) are destined to bring about the apocalypse.
King Chicken (Duckman) created the Beautex virus, which eats away matter, causing it to devolve through its various stages and then banishing it into nowhere, causing the world to nearly vanish completely.
Dr. Ivo Robotnik (Sonic the Hedgehog) preparing his Ultimate Annihilator, a satellite cannon that can utterly erase matter from reality.
Bender Bending Rodríguez (Futurama) wielding the Planetary Annihilator, which fires a deadly beam with an ever expanding diameter that annihilates all matter.
When Peter Griffin and Ernie (Family Guy) fights, the two always cause massive destruction and many casualties.
The black flames of Amaterasu (Naruto) are inextinguishable, and are so deadly that they won't stop until they burn down everything to ashes.
Obito Uchiha's (Naruto) Yin-Yang weapons can cause anything but senjutsu to cease to exist.
Dust Release are techniques that destroy matter and energy at a molecular level.
Mard Geer (Fairy Tail) can use the Memento Mori that is the ultimate curse, erasing one's existence for eternity by removing life and death.
Ichibē Hyōsube (Bleach) using Futen Daisatsuryō to completely destroy his foes with blackness, that not even their souls can reincarnate.
Baraggan Louisenbarn's (Bleach) time acceleration powers can disintegrate anything it touch from Kido Barriers to even his own Resurrección enhanced Hierro.
Anything the edge of Zanka no Tachi (Bleach) touches is eradicated into nothingness.
Zeno and his future counterpart (Dragon Ball Super) using Erase that is so absolute and powerful, it can completely annihilate an entire universe and everyone in it that even escaping to another universe is futile.
Jabberwock (Project ARMS) is an engine of destruction, with deadly abilities such as raising temperature, electromagnetic railgun, hypersonic vibration, and the deadliest is antimatter production.
Kosuke (Btooom!) setting off an Implosion BIM that can shave off all matter via its vacuum explosion.
The Azure Flame (Code:Breaker) will burn everything to nothingness.
Negation (Code:Breaker) from Pandora's Box is capable of destroying the world outright.
Rasen (Flame of Recca) can use the Kōkai Gyoku to erase anything in existence, whether it be physical, mental, or conceptual. In exchange, it takes something of equal value from the user.
Train Heartnet (Black Cat) firing an Orichalcum bullet out of Hades, which is capable of destroying any material on Earth.
Accelerator's (A Certain Magical Index) vector manipulating abilities have immense destructive potential, capable of wrecking the planet.
Hirose Yuichi's (Alive: The Final Evolution) power, Void, destroys any and all matter it hits.
Blackbeard's (One Piece) Yami Yami no Mi reduces all to nothing, while his Gura Gura no Mi destroys all.
Sailor Saturn (Sailor Moon) is the Sailor Soldier of Silence and Destruction. She uses her planetary weapon, the Silence Glaive, to utterly destroy entire worlds and planets.
Miroku (InuYasha) can destroy anything he sucks into his Kazaana.
Beerus (Dragon Ball Z: Battle of Gods), as the God of Destruction, is powerful enough to annihilate entire galaxies.
Ryner (Legend of the Legendary Heroes) is able to analyze and destroy existence.
Izayoi Sakamaki (Problem Children are Coming from Another World, Aren't They?)'s gift is Code: Unknown, allow him to destroy anything, even gifts.
Clear Note’s (Zatch Bell) spells focus on completely annihilating his opponents. Clear wants to become the mamodo king solely so he can bring genocide to his world. He even believes the destruction of his kind was the very reason he was born.