If the body part(s) are removed, any power(s) they grant will be rendered null.
Judge Dredd (2000 AD)
Shizuri Mugino (A Certain Magical Index)
Najenda (Akame Ga Kill!)
Seryu Ubiquitous (Akame Ga Kill!)
Tetsuo Shima (Akira)
Nathan Spencer (Bionic Commando)
Vera Lynn Black (DC Comics)
Adam Jensen (Deus Ex: Human Revolution)
Barret Wallace (Compilation of Final Fantasy VII)
Edward Elric (Fullmetal Alchemist)
Tōshirō Hijikata (Gintama)
Kōtarō Katsura (Gintama)
Peter Pettigrew (Harry Potter)
Mr. Wink (Hellboy II: The Golden Army)
Aoi Hinata/HE (I/O)
Raiden (Metal Gear)
Vladimir Aleksandrovich Zadornov/Ramón Gálvez Mena (Metal Gear Solid: Peace Walker)
Jax (Mortal Kombat)
Obito Uchiha (Naruto)
Madara Uchiha (Naruto)
Naruto Uzumaki (Naruto)
Morgan (One Piece)
Shiki (One Piece)
Kuzan (One Piece)
Zephyr (One Piece)
Eustass Kid (One Piece)
Bunnie D'Coolette (Sonic the Hedgehog)
Anakin Skywalker/Darth Vader (Star Wars)
Wild Dog (Time Crisis)
Vash the Stampede (Trigun)
Mukuro (Yu Yu Hakusho)
Rudol Von Stroiheim (JoJo's Bizarre Adventure)
Shizuri Mugino (A Certain Magical Index) accidentally blew her own left arm and right eye off, so she created a makeshift ones out of her Meltdowner energy before replacing it with a robotic ones.
Seryu Ubiquitous (Akame Ga Kill!) obtained artificial arms prior to her bifurcation, carrying the ability to attach various weapons and a radar to them. She also carries other modifications such replacing her tongue with a gun and an explosive device attached to her skull.
Edward Elric's (Fullmetal Alchemist) right arm and left leg were replaced with advanced automail prosthesis.
Tōshirō Hijikata (Gintama) had the matsuibō connected to his arm evolve into a Super-Electric Matsuibō RX.
Kōtarō Katsura (Gintama) had his right arm replaced with Hijikata's Super-Electric Matsuibō RX by Kagura.
Kankou (Gintama) had his left arm torn off by his son, so he replaced it with a mechanical one, though he did lose it from time to time in battle, such as against Utsuro.
Oboro (Gintama) lost his left arm to Kondo and Hijikata, so he replaced it with a robotic one, allowing him to grab onto Takasugi's sword without injury.
Peter Pettigrew (Harry Potter) was given a magical silver prosthetic hand by Voldemort, replacing the one he severed, but programmed it to strangle Pettigrew for any signs of treason.
Kiru (Karakuri) has a Mechanism as his right arm, allowing him to inject liquid methane into his victims, and then controlling the pressure and temperature to cause them to explode.
Zadornov (Metal Gear Solid: Peace Walker) has a prosthetic right hand that possesses a built-in lighter, allowing it to be used as a makeshift flamethrower and rocket.
Chiyo (Naruto) replaced her left arm with a puppet's, allowing her to install a Mechanical Light Shield Block into it.
Obito Uchiha (Naruto) lost his right arm during the Third Shinobi Great War, so Madara replaced it with the mutated substance from White Zetsu.
Madara Uchiha (Naruto) takes White Zetsu's mutated substance-arm as a replacement to his missing one, simply by linking it at the stump.
Black Arm Zephyr (One Piece) wields the gigantic Battle Smasher weaponized arm, which contains Sea Stone and powerful ammunition.
Bunnie D'Coolette (Sonic the Hedgehog) had about half of her body roboticized, granting her mechanical body components of enhanced strength.
Mukuro (Yu Yu Hakusho) suffered such extensive damage when she poured acid onto herself that her right arm has been replaced with a mechanical one, which allows her to slice through space.