Users are vastly superior to any member of their species, learning and achieving quickly and effortlessly what takes years of hard work to others, and growing substantially stronger and better with each challenge. They naturally arouse a strong admiration and desire among their kind, as they personify the pinnacle of their species, and even the most hostile are forced to acknowledge their towering superiority and amazing prowess.
Drake (Blade: Trinity) is the very first vampire, and thus possesses enhanced vampiric powers and even shapeshifting.
Captain Comet (DC Comics) is the pinnacle of human evolution.
H'el (DC Comics) is superior to all other kryptonians (Superman included), with a much stronger power-level and many other abilities.
Goku (Dragon Ball) is the most powerful and skilled Saiyan in history.
Lucy (Elfen Lied) is the Diclonius "queen," and is considered to be the most dangerous of her kind not just because of her murderous tendencies and great skill with her vectors, but because she is the only Diclonius who can naturally reproduce.
Before he lost his ability, Peter Petrelli (Heroes) could absorb enough abilities to became the most powerful Evolved Human.
The Sentry (Marvel Comics) is a prime example of superhuman Alpha.
As one of the most powerful omega-level mutants, Nate Grey (Marvel Comics) embodies the pinnacle of mutantkind.
Medaka Kurokami (Medaka Box) is as much above Abnormals as they are above humans.
Pariah (Prototype) is a perfect form of the Blacklight Virus and was believed to be the "final purpose" of life on Earth.
As the very first shapeshifter, the Alpha Shapeshifter (Supernatural), unlike his children, can freely shift from one form to the next without shedding his skin, and can even mimic clothing.
Dick Roman (Supernatural) was vastly superior to his fellow Leviathans.
Deucalion a.k.a the Demon Wolf (Teen Wolf), is the pinnacle of a werewolf, gaining strength, speed and senses that surpasses that of a normal alpha.