The user has possession of an item/weapon/object that grants omnipotent powers or Nigh Omnipotence to its wielders, allowing the user to satisfy their every desire. The item/weapon/object allows the user to become a god. The user is basically unstoppable and can do anything they want.
The Hōgyoku (Bleach) is a mighty item with the ability to manifest the desires of those around it, changing fantasy and dreams into reality. This grants many powerful abilities.
The Omni Cube (Bomberman 64) can trap galaxies into its interior, granting the wielder near invincibility and knowledge of the trapped civilizations.
The Pandora Box (Code:Breaker) contains the Negation of December 32, which is strong enough to easily wipe out the entire Earth, and inside can also grant and augment special powers to people.
The Reality Gauntlet (Danny Phantom)
The Meta-Nanites (Generator Rex) are extremely powerful nanites that allow the user control over the fabric of the universe: gravity, matter and energy, time and space, elemental forces, mechanics, and more.
The Blade of Olympus (God of War) is the most powerful weapon in the world. It was created by Zeus to end the Great War.
The Jewel of Four Souls (InuYasha) is a sacred jewel that possesses the ability to empower both humans and demons.
The Triforce (The Legend of Zelda) is the ultimate source of power in all of Hyrule. If anyone possesses the Trifroce of Power, Wisdom, and Courage, will have whatever they wish for granted.
The Infinite Gems (Marvel Comics) are six gemstones of incredible power. Any who posses them will either achieve, great power, the ability to travel through time and space, warp reality, control souls, and posses telekinetic powers. However...
...if they all are held in the Infinite Gauntlet, the bearer will gain omnipotent power.
Chaos Crystals (Sonic Boom)
Chaos Emeralds (Sonic the Hedgehog), are seven powerful gems that turn thoughts into power. However, if one manages to collect all seven, they will be granted ultimate power.
Master Emerald (Sonic the Hedgehog), is the master control to the seven Chaos Emeralds, and possess infinite and unbound powers that makes it the most powerful relic on Earth.
Sol Emeralds (Sonic the Hedgehog), are the counterparts to the Chaos Emeralds, granting the similar reality manipulating powers of space-time.
World Rings (Sonic the Hedgehog)
The Book of All Knowledge (Valkyrie Crusade) with its bearer.